CHELIDONINE MONOHYDRATE*
(+|-)-chelidonine
CAS: 20267-87-2
Molecular Formula: C20H19NO5
CHELIDONINE MONOHYDRATE* - Names and Identifiers
| Name | (+|-)-chelidonine |
| Synonyms | Diphylline (1)-Chelidonine CHELIDONINE MONOHYDRATE* [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-13-methyl-, (5bR,6S,12bS)-rel- |
| CAS | 20267-87-2 |
| EINECS | 243-662-8 |
CHELIDONINE MONOHYDRATE* - Physico-chemical Properties
| Molecular Formula | C20H19NO5 |
| Molar Mass | 353.37 |
| Density | 1.422±0.06 g/cm3(Predicted) |
| Melting Point | 135-136°C(lit.) |
| Boling Point | 507.4±50.0 °C(Predicted) |
| Specific Rotation(α) | D22 +115 ±3° (ethanol); D20 +117° (c = 3 in CHCl3) |
| Solubility | Soluble in ethanol, ether, chloroform, insoluble in water. |
| Appearance | White crystal or crystalline powder |
| Merck | 13,2061 |
| pKa | 14.11±0.20(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00069660 |
CHELIDONINE MONOHYDRATE* - Reference
| Reference Show more | 1. Zhao Lu, Jiang Jianmei, Meng Qi, et al. Changes of alkaloid content in celandine during growth period [J]. Journal of Jilin Agricultural University, 2017(5):590-595. 2. Zhang, Zhi Hong, et al. "Chelidonine inhibits TNF-α-induced inflammation by suppressing the NF-κB pathways in HCT116 cells." Phytotherapy Research 32.1 (2018): 65-75.https://doi.org/10.1002/ptr.5948 3. [IF = 4.087] Zhi Hong Zhang et al. "Chelidonine inhibits TNF‐α‐induced inflammation by suppressing the NF‐κB pathways in HCT116 cells." Phytother Res. 2018 Jan;32(1): 65-75 4. [IF = 3.205] Jialiang Pan et al. "Enrichment of chelidonine from Chelidonium majus L. using macroporous resin and its antifungal activity." J Chromatogr B. 2017 Dec;1070:7 5. [IF = 4.759] Rong Wang et al. "Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution assay to accelerate alkaloid drug discovery." J Ch 6. [IF = 3.963] Zhong-min Zhao et al. "Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine." Pastic Biochem Phys. 2019 Sep;159:51 |
CHELIDONINE MONOHYDRATE* - Introduction
(|-)-chelidonine, the chemical name of the mazine, is a nutrient, belonging to the alkaloid compound.
Nature:
- ( |-)-chelidonine is a colorless, crystalline solid with a bitter taste.
-It is soluble in organic solvents such as water, alcohols and chloroform, and insoluble in non-polar solvents such as petroleum ether and benzene.
- ( |-)-chelidonine is alkaline and can react with acids to form salts.
Use:
- ( |-)-chelidonine can be used as a flavor enhancer in the food industry to enhance the flavor of food.
-It can also be used in the field of medicine and is used as an antioxidant and a drug for lowering blood lipids.
Method:
- ( |-)-chelidonine can be extracted from celandine leaves, eggplant and other plants. Generally, the extraction is carried out by steam distillation, solvent extraction or ion exchange resin adsorption.
Safety Information:
- ( |-)-chelidonine is generally considered safe and harmless when consumed in moderation.
-but excessive intake may lead to toxic symptoms, such as nausea, vomiting, dizziness, etc.
-For specific groups of people, such as children and pregnant women, (|-)-chelidonine should be used moderately.
-When using (|-)-chelidonine related products, you should use them in accordance with the instructions to avoid excessive intake.
Nature:
- ( |-)-chelidonine is a colorless, crystalline solid with a bitter taste.
-It is soluble in organic solvents such as water, alcohols and chloroform, and insoluble in non-polar solvents such as petroleum ether and benzene.
- ( |-)-chelidonine is alkaline and can react with acids to form salts.
Use:
- ( |-)-chelidonine can be used as a flavor enhancer in the food industry to enhance the flavor of food.
-It can also be used in the field of medicine and is used as an antioxidant and a drug for lowering blood lipids.
Method:
- ( |-)-chelidonine can be extracted from celandine leaves, eggplant and other plants. Generally, the extraction is carried out by steam distillation, solvent extraction or ion exchange resin adsorption.
Safety Information:
- ( |-)-chelidonine is generally considered safe and harmless when consumed in moderation.
-but excessive intake may lead to toxic symptoms, such as nausea, vomiting, dizziness, etc.
-For specific groups of people, such as children and pregnant women, (|-)-chelidonine should be used moderately.
-When using (|-)-chelidonine related products, you should use them in accordance with the instructions to avoid excessive intake.
Last Update：2024-04-09 02:00:44
